Probably not but here's what I'm after... I want to remote into work using my Surface Book and use my 2 external monitors, mouse and keyboard for that and be able to use my Surface Book's screen for my regular home environment.
It is certainly possible, it just depends on what remote desktop software you're using.
It's a long time since I did it (10 years), so I can't recall if microsofts offering allows it, but I used to use teamviewer and have a remote desktop window on one screen for my server, while my main screen was just my computer as normal. Never tried it with 2 external monitors though.