Of course, you could. But people that wants to attach a DVD mostly are gamers or they are asked for some kind of DVD verification.Ok, couldn't you also copy all the files from a cd or a dvd into a new folder in a flash drive and then execute the .exe file? Without the need for an iso? I know there are certain things where an iso is better, for games and maybe movies as an example. But for most simple programs wouldn't copying and pasting work just as well? I have done this numerous times without any problems. Maybe I haven't looked into newer software for creating isos, in the past I always found it cumbersome and time consuming, maybe it has improved.